Data Science & Analytics
Data Translator CAM/AOP Knowledge Provider
Description
The NCATS Biomedical Data Translator project applies semantic integration strategies to share chemical, genetic, phenotypic, disease, ontological, and other ‘knowledge sources’. Taken together, the >300 knowledge sources form an integrated data ecosystem and technology platform—the Translator system—to support clinical and translational science. RENCI contributes to three Translator Projects, including the Exposures Provider Service. The CAM/AOP Knowledge Provider is a subproject of the Exposures Provider which explores integration of Causal Activity Models (CAMs) into the Translator knowledge graph. CAMs are small knowledge graphs modeled using the OWL Web Ontology Language, pioneered by the Gene Ontology project. An OWL reasoner is used to augment the CAM knowledge graphs with contextual information provided by reference ontologies. The CAM/AOP knowledge provider includes a datasets of CAMs provided by the Gene Ontology and Reactome projects, and we are also exploring publication of Adverse Outcome Pathways (AOPs) using this approach.
RENCI's Role
Ashok Krishnamurthy is the PI for the Exposures Provider Team.