Cell Cycle Browser (CCB) and TRACE (TRacking and Analysis of CEll Cycle)

The Cell Cycle Browser (CCB) is an interactive web tool for visualizing and simulating the human cell cycle to explore the timeline of molecular events during cell cycle progression. It was developed in the spirit of the UCSC Genome Browser, which provides a graphical view of genome sequence data along the physical coordinates of the chromosomes. Unlike the Genome Browser, however, the primary axis of the CCB browser is time. In its most basic functionality, the CCB displays time series data representing various molecular activities over the course of a single cell cycle. Single-cell traces from time-lapse fluorescent microscopy experiments—representing different biological activities from multiple cell lines—may be aligned in time to examine the temporal sequence of cell cycle events.

TRACE is an interactive web tool for tracking and segmenting cells from live-cell microscopy images.

David Borland and Hong Yi developed the CCB tool and the TRACE tool in collaboration with Dr. Purvis from the UNC Department of Genetics and his lab.

• UNC Department of Genetics

• National Science Foundation
• W.M. Keck Foundation